by Miller & Levine
[complete Table of Contents]
the pull-down menu to jump to any of the Book's 40 Chapters:
Chapter 14 Resources:
to the Human Genome
Our special guide to searching the human genome, including a "Scavenger
Hunt" for your students to use in exploring the genome.
Human Genome "Top Ten" List
Ten things about the human genome that we'll bet you didn't know!
Biotech Death of Jesse Gelsinger"
A moving article from the NY Times Magazine about a tragic death associated
with a gene therapy experiment
The Human Genome
chapter, students will read about the basic principles of human genetics
and the organization of the human genome, as well as techniques for manipulating
DNA, including the production of recombinant organisms. Students will
also be introduced to some of the technology being used to study and manipulate
human DNA and some of the anticipated applications of this technology
14-1: Human Heredity
All egg cells
carry a single X chromosome (23X). However, half of all sperm cells carry
an X chromosome (23X), and half carry a Y chromosome (23Y). This ensures
that just about half of the zygotes will be 46XX (female), and half will
be 46XY (male).
In both cystic fibrosis and sickle cell
disease, a small change in the DNA of a single gene affects the structure
of a protein, causing a serious genetic disorder.
14-2: Human Chromosomes
Males have just one X chromosome. Thus,
all X-linked alleles are expressed in males, even if they are recessive.
Nondisjunction causes gametes to have
abnormal numbers of chromosomes, which in turn causes a chromosome number
14-3: Human Molecular Genetics
The Human Genome Project is an attempt
to sequence all human DNA.
In gene therapy, an absent or faulty
gene is replaced by a normal, working gene.