by Miller & Levine

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Additional Chapter 14 Resources:

Gateway to the Human Genome
Our special guide to searching the human genome, including a "Scavenger Hunt" for your students to use in exploring the genome.

A Human Genome "Top Ten" List
Ten things about the human genome that we'll bet you didn't know!

"The Biotech Death of Jesse Gelsinger"
A moving article from the NY Times Magazine about a tragic death associated with a gene therapy experiment

Chapter 14
The Human Genome

In this chapter, students will read about the basic principles of human genetics and the organization of the human genome, as well as techniques for manipulating DNA, including the production of recombinant organisms. Students will also be introduced to some of the technology being used to study and manipulate human DNA and some of the anticipated applications of this technology

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Web Codes for Chapter 14:
Active Art: Pedigree
Miller & Levine: Issue: Who Controls your DNA?
Human Genome Project
SciLinks: Heredity

Section 14-1: Human Heredity
All egg cells carry a single X chromosome (23X). However, half of all sperm cells carry an X chromosome (23X), and half carry a Y chromosome (23Y). This ensures that just about half of the zygotes will be 46XX (female), and half will be 46XY (male).
In both cystic fibrosis and sickle cell disease, a small change in the DNA of a single gene affects the structure of a protein, causing a serious genetic disorder.

Section 14-2: Human Chromosomes
Males have just one X chromosome. Thus, all X-linked alleles are expressed in males, even if they are recessive.
Nondisjunction causes gametes to have abnormal numbers of chromosomes, which in turn causes a chromosome number disorder.

Section 14-3: Human Molecular Genetics
The Human Genome Project is an attempt to sequence all human DNA.
In gene therapy, an absent or faulty gene is replaced by a normal, working gene.


Insights into the Human Genome
A page of facts and figures about the Human Genome Sequencing Project.

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