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Fact # 3) We Cannot Use the Sequence to predict Protein Structure.

• This is a bummer, for several reasons. The most important is that it is difficult to tell very much about a protein just from its DNA sequence. To understand its biological activity, one must also known its detailed three-dimensional structure.

• To do this, one would like to be able to go directly from DNA sequence to a predicted structure. Unfortunately, although several labs are working very hard on the problem, ways to accurately predict protein structure are still not available. Until this goal is reached, complete interpretation of gene function and interaction will remain elusive.

 

For More Information, visit the ORNL Genome Information Site:

http://www.ornl.gov/hgmis/project/journals/insights.html

 

The Human Genome Top Ten: 10 9 8 7 6 5 4 3 2 1

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(A web site developed by Ken Miller and Joe Levine to provide scientific and education support for teachers and students using our textbooks)